Geelen A, Brouwer I A, Schouten E G, Kluft C, Katan M B, Zock P L
Wageningen Centre for Food Sciences, Wageningen University, The Netherlands.
Eur J Clin Nutr. 2004 Oct;58(10):1440-2. doi: 10.1038/sj.ejcn.1601986.
High-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, is a powerful predictor of cardiovascular risk. We hypothesised that n-3 fatty acids reduce underlying inflammatory processes and consequently CRP concentrations in healthy middle-aged subjects.
Placebo-controlled, double-blind study.
A total of 43 men and 41 postmenopausal women aged 50-70 y. Before and after intervention, we measured serum CRP concentrations with an enzyme immunoassay.
Capsules with either 3.5 g/day fish oil (1.5 g/day n-3 fatty acids) or placebo for 12 weeks.
The median CRP change in the fish oil group did not significantly differ from that in the placebo group (0.01 vs -0.17 mg/l, P = 0.057).
The currently available data--including ours--do not support that beneficial effects on CRP are involved in a mechanism explaining the protective effect on heart disease risk of n-3 fatty acids as present in fish.
高敏C反应蛋白（CRP）是全身炎症的标志物，是心血管风险的有力预测指标。我们假设n-3脂肪酸可减轻潜在的炎症过程，从而降低健康中年受试者的CRP浓度。
安慰剂对照、双盲研究。
共有43名男性和41名年龄在50至70岁之间的绝经后女性。在干预前后，我们用酶免疫测定法测量血清CRP浓度。
每天服用3.5克鱼油（1.5克n-3脂肪酸）胶囊或安慰剂，持续12周。
鱼油组CRP的中位数变化与安慰剂组无显著差异（0.01对-0.17毫克/升，P = 0.057）。
目前可得的数据——包括我们的研究数据——并不支持n-3脂肪酸对CRP的有益作用参与了解释鱼类中所含n-3脂肪酸对心脏病风险的保护作用的机制。
