Poudel-Tandukar Kalpana, Nanri Akiko, Matsushita Yumi, Sasaki Satoshi, Ohta Masanori, Sato Masao, Mizoue Tetsuya
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan.
Nutr Res. 2009 Jun;29(6):363-70. doi: 10.1016/j.nutres.2009.05.012.
Investigations suggest a protective role of n-3 polyunsaturated fatty acids (PUFA) but opposing roles of n-6 PUFA in inflammation, but the effects in vivo the human are not clear. We therefore tested the hypothesis that higher intakes of n-3 PUFA and n-6 PUFA are associated with lower levels of inflammation among a population consuming a diet high in PUFA. This study aimed to assess the association between PUFA intake and serum C-reactive protein (CRP) concentrations in a group of Japanese employees. The study subjects were 300 men and 211 women aged 21 to 67 years working in 2 municipal offices of Japan. We measured the serum high-sensitivity CRP concentrations by the latex agglutination nephelometry method and assessed dietary habits by a validated self-administered diet history questionnaire. We analyzed the data using multiple linear regression analysis with adjustment for potential confounding variables. Mean serum CRP concentrations tended to decrease as the intake of eicosapentaenoic acid, docosahexaenoic acid, or their combination increased in men and women, although none of these relationships was statistically significant. In men, there were statistically significant inverse relationships between dietary intake of n-3 or n-6 PUFA and serum CRP concentrations (P for trend = .03 and .008, respectively). Among specific PUFA, only alpha-linolenic acid and linoleic acid showed clear inverse relationships (P for trend = .001 and .003, respectively) in men. The results suggest that increased intake of not only alpha-linolenic acid (n-3 PUFA) but also linoleic acid (n-6 PUFA) has a beneficial effect on systemic inflammation in men.
调查表明，n-3多不饱和脂肪酸（PUFA）具有保护作用，而n-6 PUFA在炎症中则起相反作用，但对人体的体内影响尚不清楚。因此，我们检验了这样一个假设：在食用富含PUFA饮食的人群中，较高的n-3 PUFA和n-6 PUFA摄入量与较低的炎症水平相关。本研究旨在评估一组日本员工中PUFA摄入量与血清C反应蛋白（CRP）浓度之间的关联。研究对象为在日本两个市政办公室工作的300名男性和211名女性，年龄在21至67岁之间。我们采用乳胶凝集比浊法测量血清高敏CRP浓度，并通过一份经过验证的自填式饮食史问卷评估饮食习惯。我们使用多元线性回归分析对数据进行分析，并对潜在的混杂变量进行了调整。男性和女性的血清CRP平均浓度均倾向于随着二十碳五烯酸、二十二碳六烯酸或其组合摄入量的增加而降低，尽管这些关系均无统计学意义。在男性中，n-3或n-6 PUFA的饮食摄入量与血清CRP浓度之间存在统计学显著的负相关关系（趋势P值分别为0.03和0.008）。在特定的PUFA中，只有α-亚麻酸和亚油酸在男性中显示出明显的负相关关系（趋势P值分别为0.001和0.003）。结果表明，不仅增加α-亚麻酸（n-3 PUFA）的摄入量，而且增加亚油酸（n-6 PUFA）的摄入量，对男性的全身炎症都有有益影响。
