Schmidt Joerg C, Rodrigues Eduardo B, Meyer Carsten H, Hoerle Steffen, Kroll Peter
Department of Ophthalmology, Philipps University, Marburg, Germany.
Ophthalmologica. 2004 May-Jun;218(3):176-9. doi: 10.1159/000076841.
Peeling of the internal limiting membrane (ILM) has improved the outcomes in vitreoretinal surgery of macular diseases. Indocyanine green (ICG) is used to stain and improve the visualization of the ILM. This paper aims to describe a modified approach to stain and peel the ILM avoiding potential adverse side effects.
After a core vitrectomy, 0.05 ml of ICG in a concentration of 5 mg/ml is quickly injected under water around the macular region. The tip of the syringe is positioned about 5 mm from the macular tissue, in a way that about a 3-mm diameter area around the fovea is stained by the ICG. Additional ICG is immediately removed by aspiration. Peeling of the ILM is accomplished with a forceps.
Neither residual ICG in the vitreous cavity nor any clinical signs of phototoxicity like retinal edema were detected in any patients operated by this technique.
This modified technique to stain the ILM limits the amount and concentration of ICG. The locally limited contact of ICG with the retinal surface seems to be a safe procedure to stain the ILM.
内界膜（ILM）剥除术改善了黄斑疾病玻璃体视网膜手术的效果。吲哚菁绿（ICG）用于染色并改善ILM的可视化。本文旨在描述一种改良方法，用于染色和剥除ILM，避免潜在的不良副作用。
在进行核心玻璃体切除术后，将0.05 ml浓度为5 mg/ml的ICG在水下快速注射到黄斑区域周围。注射器尖端距黄斑组织约5 mm，以使中央凹周围约3 mm直径的区域被ICG染色。通过抽吸立即去除多余的ICG。用镊子完成ILM的剥除。
采用该技术进行手术的所有患者均未在玻璃体腔中检测到残留的ICG，也未发现任何光毒性的临床体征，如视网膜水肿。
这种改良的ILM染色技术限制了ICG的用量和浓度。ICG与视网膜表面的局部有限接触似乎是一种对ILM进行染色的安全方法。
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