从巴西红厚壳中提取的具有抗菌活性的新型色满酮酸

New chromanone acids with antibacterial activity from Calophyllum brasiliense.

作者信息

Cottiglia Filippo, Dhanapal Boopathy, Sticher Otto, Heilmann Jörg

机构信息

Dipartimento Farmaco Chimico Tecnologico, Facoltà di Farmacia, University of Cagliari, 09124 Cagliari, Italy.

出版信息

J Nat Prod. 2004 Apr;67(4):537-41. doi: 10.1021/np030438n.

DOI:10.1021/np030438n

PMID:15104480

Abstract

Six novel chromanone acids (1-6) were isolated from the bark of Calophyllum brasiliense Cambess. Their structures were elucidated on the basis of 1D and 2D NMR experiments, as well as mass spectrometry. All compounds showed moderate to strong antibacterial activity against Bacillus cereus and Staphylococcus epidermidis, with 1 and 2 being most active. None of the compounds were cytotoxic against KB, Jurkat T, and myosarcoma cancer cells up to 20 microg/mL.

摘要

从巴西红厚壳（Calophyllum brasiliense Cambess.）树皮中分离出六种新型色满酮酸（1-6）。基于一维和二维核磁共振实验以及质谱分析确定了它们的结构。所有化合物对蜡状芽孢杆菌和表皮葡萄球菌均表现出中度至强抗菌活性，其中1和2活性最强。在浓度高达20μg/mL时，所有化合物对KB、Jurkat T和骨肉瘤癌细胞均无细胞毒性。