杨叶肖槿中的细胞毒性和抗菌倍半萜类化合物。

Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.

作者信息

Boonsri Sompong, Karalai Chatchanok, Ponglimanont Chanita, Chantrapromma Suchada, Kanjana-Opas Akkharawit

机构信息

Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.

出版信息

J Nat Prod. 2008 Jul;71(7):1173-7. doi: 10.1021/np800055q. Epub 2008 Jun 14.

DOI:10.1021/np800055q

PMID:18553924

Abstract

Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.

摘要

从杨叶肖槿的木材和深色心材的二氯甲烷提取物中分离出8种新的倍半萜类化合物，命名为杨叶肖槿烯A-H（1-8），同时还分离出11种已知化合物（9-19）。通过光谱分析确定了它们的结构。对分离出的化合物针对四种癌细胞系：MCF-7、HeLa、HT-29和KB进行了细胞毒性活性评估。曼森酮E（11）和（+）-棉酚（18）表现出显著活性。还展示了它们对枯草芽孢杆菌、金黄色葡萄球菌和粪肠球菌的抗菌特性。