益母草的半日花烷二萜类化合物。

Labdane diterpenes of Leonurus sibiricus.

作者信息

Boalino Dionne M, McLean Stewart, Reynolds William F, Tinto Winston F

机构信息

Laboratory of Bioorganic Chemistry, Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, Bridgetown, Barbados.

出版信息

J Nat Prod. 2004 Apr;67(4):714-7. doi: 10.1021/np030480i.

DOI:10.1021/np030480i

PMID:15104513

Abstract

Seven new labdane diterpenes, sibiricinones A-E (1-4, 6) and 15-epi-sibiricinones D and E (5 and 7), and the flavone genkwanin were isolated from the aerial parts of Leonurus sibiricus. Sibiricinone D (4) and 15-epi-sibiricinone D (5), and sibiricinone E (6) and 15-epi-sibiricinone E (7), respectively, were isolated as C-15 epimeric pairs. These secondary metabolites were identified on the basis of 1D and 2D NMR including (1)H-(1)H COSY, HSQC, and HMBC spectroscopic techniques. The stereochemical configurations of compounds 4-7 were assigned through 2D T-ROESY and selective NOE experiments.

摘要

从益母草地上部分分离得到7个新的半日花烷二萜类化合物，即西伯利亚酮A - E（1 - 4, 6）和15 - 表西伯利亚酮D和E（5和7），以及黄酮类化合物芫花素。西伯利亚酮D（4）和15 - 表西伯利亚酮D（5），以及西伯利亚酮E（6）和15 - 表西伯利亚酮E（7）分别作为C - 15差向异构体对被分离出来。这些次生代谢产物是基于一维和二维核磁共振，包括（1）H - （1）H COSY、HSQC和HMBC光谱技术鉴定的。化合物4 - 7的立体化学构型通过二维T - ROESY和选择性NOE实验确定。