来自塞萨洛尼基夏至草的半日花烷二萜类化合物。

Labdane diterpenes from Marrubium thessalum.

作者信息

Argyropoulou Catherine, Karioti Anastasia, Skaltsa Helen

机构信息

Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, Panepistimiopolis, Zografou, GR-15771 Athens, Greece.

出版信息

Phytochemistry. 2009 Mar;70(5):635-40. doi: 10.1016/j.phytochem.2009.03.011. Epub 2009 Apr 8.

DOI:10.1016/j.phytochem.2009.03.011

PMID:19361824

Abstract

From the aerial parts of Marrubium thessalum, four labdane diterpenes, 13S-preperegrinine, 3alpha-hydroxymarrubiin, 9alpha,13R-15,16-bisepoxy-15beta-methoxy-3-oxo-labdan-6beta,19-olide and 15-methoxyvelutine C, have been isolated together with four known diterpenes and one methoxylated flavone, ladanein. The structures of the isolated compounds were established by means of NMR (COSY, HSQC, HMBC, NOESY, and ROESY) and MS spectral analyses. Complete NMR assignments are reported for 13R-preperegrinine. Characteristic compounds of the plant were peregrinine and ladanein.

摘要

从绵毛水苏的地上部分分离出了四种半日花烷二萜，即13S-前佩雷格林宁、3α-羟基绵毛水苏素、9α,13R-15,16-双环氧-15β-甲氧基-3-氧代-半日花烷-6β,19-内酯和15-甲氧基绒毛水苏素C，还分离出了四种已知的二萜和一种甲氧基黄酮，即半日花素。通过核磁共振（COSY、HSQC、HMBC、NOESY和ROESY）和质谱分析确定了分离出的化合物的结构。报道了13R-前佩雷格林宁的完整核磁共振归属。该植物的特征性化合物是佩雷格林宁和半日花素。