Mathias Richard T, Rae James L
Department of Physiology and Biophysics, State University of New York, Stony Brook, NY 11794-8661, USA.
Exp Eye Res. 2004 Mar;78(3):689-98. doi: 10.1016/j.exer.2003.07.001.
The perception of the lens changed remarkably during the career of David Maurice. The early view was that it was an inert sack of protein that assisted the cornea in focusing light on the retina. As investigators looked more carefully, more and more complexity was revealed and today we know the lens is a living, dynamic organ that carries out a host of biochemical and physiological processes necessary for homeostasis. We have worked on the lens over this period and have provided a small part of the data on lens physiology. This paper is an overview of our own contributions, in the context of the ever evolving view of the lens. Given this is a brief tribute to the career of David Maurice, there is not enough space nor is it appropriate to provide a complete review of all the work that has contributed to this evolving
在大卫·莫里斯的职业生涯中,人们对晶状体的认识发生了显著变化。早期的观点认为,它是一个惰性的蛋白质囊袋,协助角膜将光线聚焦在视网膜上。随着研究人员更加仔细地观察,越来越多的复杂性被揭示出来,如今我们知道晶状体是一个有生命的、动态的器官,它执行着内环境稳态所需的一系列生化和生理过程。在此期间,我们一直致力于晶状体的研究,并提供了有关晶状体生理学的一小部分数据。本文是在对晶状体不断演变的认识背景下,对我们自己贡献的概述。鉴于这是对大卫·莫里斯职业生涯的简短致敬,没有足够的篇幅,也不适合对促成这种演变的所有工作进行全面回顾。