Li Ji-Liang, Harris Adrian L
Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.
Cancer Cell. 2005 Jul;8(1):1-3. doi: 10.1016/j.ccr.2005.06.013.
Notch signaling is an evolutionarily conserved pathway and plays key roles in embryonic vascular development and angiogenesis. Multiple components of the Notch pathway are expressed in vasculature, and mice deficient for a variety of these components display embryonic lethality with vascular remodeling defects. Alteration of Notch signaling in various endothelial cells generates profound effects on angiogenesis in vitro. New evidence shows that Notch signaling from tumor cells is able to activate endothelial cells and trigger tumor angiogenesis in vitro and in a xenograft mouse tumor model. Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy.
Notch信号通路是一条在进化上保守的信号通路，在胚胎血管发育和血管生成中发挥关键作用。Notch信号通路的多个组分在脉管系统中表达，并且缺乏这些组分中多种组分的小鼠表现出具有血管重塑缺陷的胚胎致死性。在各种内皮细胞中Notch信号的改变在体外对血管生成产生深远影响。新证据表明，来自肿瘤细胞的Notch信号能够激活内皮细胞，并在体外和异种移植小鼠肿瘤模型中触发肿瘤血管生成。肿瘤内Notch信号的选择性阻断可能提供一种抗血管生成策略。
