分子命运三女神：造血干细胞命运的长链非编码RNA调节因子
Molecular Moirai: Long Noncoding RNA Mediators of HSC Fate.
作者信息
Magilnick Nathaniel, Boldin Mark P
出版信息
Curr Stem Cell Rep. 2018 Jun;4(2):158-165. doi: 10.1007/s40778-018-0130-z. Epub 2018 Apr 16.
PURPOSE OF REVIEW
Hematopoiesis is an ordered developmental process that requires dynamic regulation to warrant proper response to physiological challenges and prevent malignancies. Long noncoding RNAs are emerging as key, multi-faceted regulators of gene expression. This review explores the function of lncRNAs in the control of HSC homeostasis and hematopoietic differentiation.
RECENT FINDINGS
Multiple lncRNAs have been implicated in maintaining HSC stemness and enabling progenitors to carry out the correct programs of lineage differentiation. Specific lncRNAs have been identified that regulate the differentiation of multipotent progenitors into terminally differentiated blood cells. These lncRNAs predominantly act by assisting master regulators that drive specific differentiation programs, either by enhancing or repressing the transcription of particular genomic loci.
SUMMARY
Long noncoding RNAs contribute to the correct differentiation and maturation of various hematopoietic lineages by assisting with the activation of transcriptional programs in a time- and cell-dependent manner.
综述目的
造血作用是一个有序的发育过程，需要动态调节以确保对生理挑战做出适当反应并预防恶性肿瘤。长链非编码RNA正成为基因表达的关键、多方面的调节因子。本综述探讨了lncRNA在控制造血干细胞稳态和造血分化中的作用。
最新发现
多种lncRNA参与维持造血干细胞干性，并使祖细胞能够执行正确的谱系分化程序。已鉴定出特定的lncRNA，它们调节多能祖细胞向终末分化血细胞的分化。这些lncRNA主要通过协助驱动特定分化程序的主调节因子发挥作用，要么增强要么抑制特定基因组位点的转录。
总结
长链非编码RNA通过以时间和细胞依赖性方式协助转录程序的激活，促进各种造血谱系的正确分化和成熟。
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