Diessler M E, Castellano M C, Massone A R, Portiansky E L, Allende M G, Idiart J R, Gimeno E J
Institute of Pathology, Faculty of Veterinary Sciences, National University of La Plata, La Plata, Argentina.
J Vet Med A Physiol Pathol Clin Med. 2003 Nov;50(9):452-6. doi: 10.1046/j.1439-0442.2003.00573.x.
Lymphangiosarcoma is a rare tumour in domestic animals arising from lymphatic endothelial cells. Occasionally, microscopic differentiation with haemangiosarcoma may be difficult. The aim of the present study was to describe a lymphangiosarcoma in a 1-year-old female Doberman Pinscher dog and to characterize its lectinhistochemical binding pattern as compared with that of haemangiosarcoma. The dog was presented because of a cutaneous painful swelling located in the left axilla. Histological diagnosis confirmed lymphangiosarcoma. The dog was killed. Necropsy revealed mediastinal lymph nodes' involvement. Twenty lectins were tested in tissue sections of this case as well as in four haemangiosarcomas from other dogs. Staining intensity was issued upon optical density determinations. Percentage of lectinhistochemical staining area was also conducted. RCA-I showed the most intense and wide distributed labelling pattern for lymphangiosarcoma. PHA-E was the counterpart for haemangiosarcoma. Should similar results be obtained in further studies, such differences could aid in the differential diagnosis between lymphangiosarcoma and haemangiosarcoma when histological pictures were not conclusive.
淋巴管肉瘤是家畜中一种罕见的由淋巴管内皮细胞产生的肿瘤。偶尔，与血管肉瘤进行微观鉴别可能会很困难。本研究的目的是描述一只1岁雌性杜宾犬身上的淋巴管肉瘤，并与血管肉瘤相比，对其凝集素组织化学结合模式进行特征描述。这只狗因左腋窝处皮肤疼痛性肿胀前来就诊。组织学诊断证实为淋巴管肉瘤。这只狗被安乐死。尸检发现纵隔淋巴结受累。在该病例的组织切片以及来自其他狗的四个血管肉瘤中测试了二十种凝集素。根据光密度测定确定染色强度。还进行了凝集素组织化学染色面积百分比的测定。RCA-I对淋巴管肉瘤显示出最强且分布最广的标记模式。PHA-E则是血管肉瘤的对应物。如果在进一步研究中获得类似结果，当组织学图像不明确时，这种差异可能有助于淋巴管肉瘤和血管肉瘤之间的鉴别诊断。
