Looper Jayme S
Department of Radiation Oncology, VCA Aurora Animal Hospital, 2600 West Galena Blvd, Aurora, IL, USA.
Vet Radiol Ultrasound. 2007 Jan-Feb;48(1):86-8. doi: 10.1111/j.1740-8261.2007.00209.x.
A 4.5-year-old neutered male dog was diagnosed with incompletely excised well-differentiated lymphangiosarcoma in the right inguinal subcutaneous region. The mass had metastasized to the right hypogastric and medial iliac lymph nodes. Surgery followed by definitive radiation therapy was administered to the primary site and the sites of metastasis. The dog had a complete response to radiotherapy, and minimal acute side effects. Doxorubicin was administered after radiotherapy. Approximately 4 months following radiation therapy, the dog developed a mass, presumed recurrent tumor, in the original site. In a biopsy only steatitis and fibrosis were found. The mass continued to grow and conservative surgical excision was elected. Histopathologically the diagnosis was fat necrosis and steatitis, with a microscopic focus of lymphangiosarcoma. Fat necrosis is an uncommon sequelum to breast irradiation in people and also appears to be rare in animals. Fat necrosis should be considered as a differential diagnosis when recurrent tumor is suspected in a previously irradiated subcutaneous site in a dog.
一只4.5岁已绝育的雄性犬被诊断为右侧腹股沟皮下区域的高分化淋巴管肉瘤切除不完全。肿瘤已转移至右下腹和髂内淋巴结。对原发部位和转移部位进行了手术，随后进行了根治性放射治疗。这只犬对放疗完全缓解，且急性副作用极小。放疗后给予了阿霉素。放疗后约4个月，这只犬在原部位出现一个肿块，推测为复发性肿瘤。活检仅发现脂肪炎和纤维化。肿块持续生长，遂选择保守手术切除。组织病理学诊断为脂肪坏死和脂肪炎，伴有微小的淋巴管肉瘤病灶。脂肪坏死在人类中是乳腺放疗不常见的后遗症，在动物中似乎也很少见。当怀疑犬先前接受过放疗的皮下部位出现复发性肿瘤时，应考虑脂肪坏死作为鉴别诊断。
