Nolph K D, Twardowski Z J, Keshaviah P R
Division of Nephrology, University of Missouri Health Sciences Center, Columbia 65212.
Perit Dial Int. 1992;12(3):298-303.
Weekly creatinine clearance (Ccr) and weekly Curea/v (kt/v) are popular indices for quantitating the amount of peritoneal dialysis provided. Studies were undertaken on 44 patients on continuous ambulatory peritoneal dialysis (CAPD) and 10 patients on nightly intermittent peritoneal dialysis (NIPD) to compare relationships of weekly creatinine clearance to weekly urea clearance (Curea) divided by total body water (v). With a long cycle therapy such as CAPD, the ratio of weekly Ccr to weekly kt/v is higher than with a short cycle technique, such as NIPD, in the same patient. If patients are shifted from CAPD to NIPD maintaining the same weekly kt/v, the weekly Ccr will decrease. If patients are shifted from CAPD to NIPD maintaining the same weekly Ccr, then the weekly kt/v will increase. The clinical implications of these observations are unknown, but should be kept in mind for future studies comparing CAPD and NIPD.
每周肌酐清除率（Ccr）和每周尿素清除率/总体水（kt/v）是用于量化腹膜透析量的常用指标。对44例持续性非卧床腹膜透析（CAPD）患者和10例夜间间歇性腹膜透析（NIPD）患者进行了研究，以比较每周肌酐清除率与每周尿素清除率（Curea）除以总体水（v）之间的关系。在同一患者中，与短周期技术（如NIPD）相比，长周期治疗（如CAPD）时每周Ccr与每周kt/v的比值更高。如果患者从CAPD转为NIPD并维持相同的每周kt/v，则每周Ccr会降低。如果患者从CAPD转为NIPD并维持相同的每周Ccr，则每周kt/v会增加。这些观察结果的临床意义尚不清楚，但在未来比较CAPD和NIPD的研究中应予以考虑。
