3型腺病毒利用CD80（B7.1）和CD86（B7.2）作为细胞附着受体。

Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors.

作者信息

Short Joshua J, Pereboev Alexander V, Kawakami Yosuke, Vasu Chenthamarakshan, Holterman Mark J, Curiel David T

机构信息

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294-2172, USA.

出版信息

Virology. 2004 May 1;322(2):349-59. doi: 10.1016/j.virol.2004.02.016.

DOI:10.1016/j.virol.2004.02.016

PMID:15110532

Abstract

Most viruses exploit a variety of host cellular proteins as primary cellular attachment receptors in the context of successful execution of infection. Furthermore, many viral agents have evolved precise mechanisms to subvert host immune recognition to achieve persistence. Herein we present data indicating that adenovirus (Ad) serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. CD80 and CD86 are co-stimulatory molecules that are present on mature dendritic cells and B lymphocytes and are involved in stimulating T-lymphocyte activation. To our knowledge, this is one of the first demonstrations of a virus utilizing immunologic accessory molecules as a primary means of cellular entry. This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system.

摘要

在成功感染的情况下，大多数病毒利用多种宿主细胞蛋白作为主要的细胞附着受体。此外，许多病毒因子已经进化出精确的机制来颠覆宿主免疫识别以实现持续性感染。在此我们展示的数据表明，3型腺病毒（Ad）利用CD80（B7.1）和CD86（B7.2）作为细胞附着受体。CD80和CD86是共刺激分子，存在于成熟的树突状细胞和B淋巴细胞上，并参与刺激T淋巴细胞活化。据我们所知，这是首次证明病毒利用免疫辅助分子作为细胞进入的主要方式之一。这一发现提示了一种机制，即病毒将这些蛋白用作受体可能实现细胞进入和逃避免疫系统这两个目标。