Richardson Tristan, Rozkovec Adrian, Thomas Peter, Ryder Jacqueline, Meckes Candy, Kerr David
Bournemouth Diabetes & Endocrine Centre, Royal Bournemouth Hospital, Bournemouth, UK.
Diabetes Care. 2004 May;27(5):1127-31. doi: 10.2337/diacare.27.5.1127.
The effect of caffeine on cardiovascular health remains controversial. Patients with long-standing type 1 diabetes are at risk of autonomic failure and sudden cardiac death. We investigated the effects of caffeine on autonomic dysfunction (as assessed by heart rate variability [HRV]) in this high-risk group and in a control population.
Using a randomized blinded, placebo-controlled, crossover design trial, we examined 2 weeks of caffeine consumption (250 mg twice daily) on HRV in 20 type 1 diabetic patients and 10 matched healthy volunteers.
Baseline HRV was blunted in the diabetic patients (P < 0.0005 vs. control subjects) and markedly increased by caffeine in both groups (+103% in the group with diabetes [P = 0.009] and +38% in control subjects [P = 0.002]). The caffeine-associated increase in HRV was not statistically different between the control and the type 1 diabetes groups (P = 0.16).
Modest amounts of caffeine improved autonomic function in diabetic patients and healthy volunteers. For individuals with abnormal HRV, regular caffeine use may have the potential to reduce the risk of cardiovascular events.
咖啡因对心血管健康的影响仍存在争议。长期患有1型糖尿病的患者存在自主神经功能衰竭和心源性猝死的风险。我们研究了咖啡因对这一高危人群以及对照人群自主神经功能障碍（通过心率变异性[HRV]评估）的影响。
采用随机双盲、安慰剂对照、交叉设计试验，我们检测了20名1型糖尿病患者和10名匹配的健康志愿者在摄入咖啡因2周（每日两次，每次250毫克）后的HRV情况。
糖尿病患者的基线HRV降低（与对照受试者相比，P<0.0005），两组摄入咖啡因后HRV均显著增加（糖尿病组增加103%[P = 0.009]，对照受试者增加38%[P = 0.002]）。对照组和1型糖尿病组之间，咖啡因引起的HRV增加在统计学上无差异（P = 0.16）。
适量咖啡因可改善糖尿病患者和健康志愿者的自主神经功能。对于HRV异常的个体，定期饮用咖啡因可能有降低心血管事件风险的潜力。
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