Rauh Robert, Burkert Michaela, Siepmann Martin, Mueck-Weymann Michael
Department for Cellular and Molecular Physiology, University Erlangen-Nürnberg, Erlangen, Germany.
Clin Physiol Funct Imaging. 2006 May;26(3):163-6. doi: 10.1111/j.1475-097X.2006.00663.x.
During the last years, heart rate variability (HRV) has become a promising risk factor for cardiovascular events. However, the effect of caffeine on HRV in habitual caffeine consumers has barely been investigated. Therefore, we treated 30 male habitual caffeine users in a randomized double-blinded crossover study design with either placebo, 100 or 200 mg caffeine orally and determined parameters of HRV under resting conditions and metronomic breathing. As result, we could not detect significant differences in HRV parameters up to 90 min after drug ingestion. We conclude that modest amounts of caffeine do not reveal negative nor positive effects on HRV within the first 90 min after drug ingestion in young and healthy habitual caffeine consumers. However, further research is necessary to determine the effects of caffeine on HRV in habitual caffeine users, healthy as well as suffering from diabetes, hypertension and postmyocardial infarction.
在过去几年中，心率变异性（HRV）已成为心血管事件一个很有前景的风险因素。然而，咖啡因对习惯性咖啡因消费者心率变异性的影响几乎未被研究。因此，我们采用随机双盲交叉研究设计，对30名男性习惯性咖啡因使用者分别口服安慰剂、100毫克或200毫克咖啡因，并在静息状态和节拍呼吸条件下测定心率变异性参数。结果，在药物摄入后90分钟内，我们未检测到心率变异性参数有显著差异。我们得出结论，在年轻健康的习惯性咖啡因消费者中，适量咖啡因在药物摄入后的前90分钟内对心率变异性未显示出负面或正面影响。然而，有必要进一步研究以确定咖啡因对习惯性咖啡因使用者（包括健康者以及患有糖尿病、高血压和心肌梗死后的患者）心率变异性的影响。
