Roestenberg Peggy, van Nieuwenhoven Frans A, Wieten Lotte, Boer Peter, Diekman Theo, Tiller Anna M, Wiersinga Wilmar M, Oliver Noelynn, Usinger William, Weitz Stephen, Schlingemann Reinier O, Goldschmeding Roel
Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.
Diabetes Care. 2004 May;27(5):1164-70. doi: 10.2337/diacare.27.5.1164.
Connective tissue growth factor (CTGF) is strongly upregulated in fibrotic disorders and has been hypothesized to play a role in the development and progression of diabetes complications. The aim of the present study was to investigate the possible association of plasma CTGF levels in type 1 diabetic patients with markers relevant to development of diabetes complications.
Plasma CTGF levels (full-length and NH2-terminal fragments) were determined in 62 well-characterized patients with type 1 diabetes and in 21 healthy control subjects. Correlations of these plasma CTGF levels with markers of glycemic control, platelet activation, endothelial activation, nephropathy, and retinopathy were investigated.
-Elevated plasma NH2-terminal fragment of CTGF (CTGF-N) levels were detected in a subpopulation of type 1 diabetic patients and were associated with diabetic nephropathy. Stepwise regression analysis revealed contribution of albuminuria, creatinine clearance, and duration of diabetes as predictors of plasma CTGF-N level. Elevation of plasma CTGF-N levels in patients with retinopathy was probably due to renal comorbidity.
Plasma CTGF-N levels are elevated in type 1 diabetic patients with nephropathy and appear to be correlated with proteinuria and creatinine clearance. Further studies will be needed to determine the relevance of plasma CTGF as a clinical marker and/or pathogenic factor in diabetic nephropathy.
结缔组织生长因子(CTGF)在纤维化疾病中强烈上调,据推测其在糖尿病并发症的发生和发展中起作用。本研究的目的是调查1型糖尿病患者血浆CTGF水平与糖尿病并发症相关标志物之间的可能关联。
测定了62例特征明确的1型糖尿病患者和21名健康对照者的血浆CTGF水平(全长和氨基末端片段)。研究了这些血浆CTGF水平与血糖控制、血小板活化、内皮活化、肾病和视网膜病变标志物之间的相关性。
在一部分1型糖尿病患者中检测到血浆CTGF的氨基末端片段(CTGF-N)水平升高,且与糖尿病肾病相关。逐步回归分析显示蛋白尿、肌酐清除率和糖尿病病程是血浆CTGF-N水平的预测因素。视网膜病变患者血浆CTGF-N水平升高可能归因于肾脏合并症。
1型糖尿病肾病患者血浆CTGF-N水平升高,且似乎与蛋白尿和肌酐清除率相关。需要进一步研究以确定血浆CTGF作为糖尿病肾病临床标志物和/或致病因素的相关性。