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T1-T2 声门癌的管理

Management of T1-T2 glottic carcinomas.

作者信息

Mendenhall William M, Werning John W, Hinerman Russell W, Amdur Robert J, Villaret Douglas B

机构信息

Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, Florida 32610-0385, USA.

出版信息

Cancer. 2004 May 1;100(9):1786-92. doi: 10.1002/cncr.20181.

Abstract

T1-T2 glottic carcinomas may be treated with conservative surgery or radiotherapy. The goals of treatment are cure and laryngeal voice preservation. The aim of the current study was to review the pertinent literature and discuss the optimal management of early-stage laryngeal carcinoma. Literature review indicated that the local control, laryngeal preservation, and survival rates of patients were similar after transoral laser resection, open partial laryngectomy, and radiotherapy. Voice quality depended on the extent of resection for patients undergoing surgery; results for patients undergoing laser resection for limited lesions were comparable to the corresponding results for patients receiving radiotherapy, whereas open partial laryngectomy yielded poorer results. Costs were similar for laser resection and radiotherapy, but open partial laryngectomy was more expensive. Patients with well defined lesions suitable for transoral laser excision with a good functional outcome were treated with either laser or radiotherapy. The remaining patients were optimally treated with radiotherapy. Open partial laryngectomy was reserved for patients with locally recurrent tumors.

摘要

T1-T2 声门癌可采用保守手术或放射治疗。治疗目标是治愈并保留喉功能。本研究的目的是回顾相关文献并讨论早期喉癌的最佳治疗方案。文献综述表明,经口激光切除术、开放性部分喉切除术和放射治疗后,患者的局部控制率、喉保留率和生存率相似。接受手术患者的语音质量取决于切除范围;对于局限性病变接受激光切除术的患者,其结果与接受放射治疗的患者相应结果相当,而开放性部分喉切除术的结果较差。激光切除术和放射治疗的费用相似,但开放性部分喉切除术费用更高。对于病变明确、适合经口激光切除且功能预后良好的患者,可采用激光或放射治疗。其余患者则首选放射治疗。开放性部分喉切除术仅用于局部复发肿瘤患者。

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