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早期声门癌的立体定向体部放射治疗:这是“正确之路”吗?

Stereotactic body radiotherapy for early glottic cancers: Is this "The Way"?

作者信息

Le Guévelou Jennifer, Larnaudie Audrey, Blanchard Pierre, Pointreau Yoann, Castelli Joël

机构信息

Laboratoire de traitement de l'image et du signal, University of Rennes, France.

Department of Research, Centre Eugène Marquis, Rennes, France.

出版信息

Clin Transl Radiat Oncol. 2025 Apr 13;53:100962. doi: 10.1016/j.ctro.2025.100962. eCollection 2025 Jul.

Abstract

In the past decades, several options have been designed in order to preserve vocal function in patients with early glottic cancer, such as transoral laser microsurgery, new surgical strategies such as partial laryngectomy and radiation therapy (RT). With the development of new radiation techniques enabling a more accurate delivery of radiation dose, and the possibility to deliver high dose per fraction while sparing adjacent organs-at-risks (OARs), stereotactic body radiotherapy (SBRT) is being increasingly tested in this disease setting. We aimed to shed light on this appealing strategy, as well as to underline both optimal target population and specific technical considerations.

摘要

在过去几十年里,为了保留早期声门癌患者的发声功能,已经设计了多种方案,如经口激光显微手术、部分喉切除术等新的手术策略以及放射治疗(RT)。随着能够更精确地给予放射剂量的新放射技术的发展,以及在 sparing adjacent organs-at-risks(OARs)的同时每次分割给予高剂量的可能性,立体定向体部放射治疗(SBRT)正在这种疾病背景下越来越多地得到测试。我们旨在阐明这种有吸引力的策略,并强调最佳目标人群和具体技术考量。

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Stereotactic Radiation Therapy in 3 Fractions for T1 Glottic Cancer.T1期声门癌的3分割立体定向放射治疗
Int J Radiat Oncol Biol Phys. 2025 Jan 1;121(1):145-152. doi: 10.1016/j.ijrobp.2024.09.051. Epub 2024 Oct 1.
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Early Closure of a Phase 1 Clinical Trial for SABR in Early-Stage Glottic Cancer.早期声门型喉癌立体定向消融放疗 1 期临床试验早期关闭。
Int J Radiat Oncol Biol Phys. 2019 Sep 1;105(1):104-109. doi: 10.1016/j.ijrobp.2019.03.011. Epub 2019 Mar 14.

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