Weeraratna Ashani T, Nagel James E, de Mello-Coelho Valeria, Taub Dennis D
Clinical Immunology Section, Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Nathan Shock Dr, Baltimore, Maryland, USA.
J Clin Immunol. 2004 May;24(3):213-24. doi: 10.1023/B:JOCI.0000025443.44833.1d.
With the mapping of the human genome comes the ability to identify genes of interest in specific diseases and the pathways involved therein. Laboratory technology has evolved in parallel, providing us with the ability to assay thousands of these genes at once, a technique known as microarray analysis. The main question that this type of technology raises is how we can apply this powerful technology to clinical medicine. Recently, advances in data analysis, as well as standardization of the technology, have allowed us to examine this question, and indeed a few clinical trials currently being performed include microarrays as part of their protocol. In this review we outline the microarray technique and describe these types of studies in further detail.
随着人类基因组图谱的绘制完成,人们有能力识别特定疾病中感兴趣的基因及其相关途径。实验室技术也在同步发展,使我们能够一次性检测数千个这类基因,这种技术称为微阵列分析。这类技术引发的主要问题是,我们如何将这项强大的技术应用于临床医学。最近,数据分析的进展以及技术的标准化使我们能够审视这个问题,实际上目前正在进行的一些临床试验已将微阵列作为其方案的一部分。在本综述中,我们概述了微阵列技术,并更详细地描述了这类研究。