Jacobs Roland, Weber Klaus, Wendt Katy, Heiken Hans, Schmidt Reinhold E
Division of Clinical Immunology, Hannover Medical School, Hannover, Germany.
J Clin Immunol. 2004 May;24(3):281-6. doi: 10.1023/B:JOCI.0000025449.16468.6f.
HIV patients either on highly active antiviral therapy (HAART) or therapy naive were analyzed for their CD56 phenotype and cytokine production in comparison to healthy controls (HC). Both NK cell populations (CD56(dim) and CD56(bright)) are found to be present in all groups with selectively decreased CD56(dim) NK cells in HAART naive patients. Patients on HAART exhibited significantly diminished numbers of CD161+CD56(dim) NK cells. CD56(dim) were equally potent in producing IFNgamma in all three groups. The number of TNFalpha+CD56(bright) NK cells from patients on HAART and TNFalpha+CD56(dim) NK cells from HAART naive patients was significantly reduced as compared to healthy controls. In summary our data revealed that functional capacities and coexpression patterns of lectin-like receptors on lymphocytes are differentially affected in HIV patients depending on the state of therapy (under HAART or HAART naive) or the cell type (NK or T cells), respectively.
对接受高效抗逆转录病毒治疗（HAART）的HIV患者以及未接受过治疗的患者进行分析，比较他们与健康对照者（HC）的CD56表型和细胞因子产生情况。发现所有组中均存在两种自然杀伤细胞群体（CD56(dim)和CD56(bright)），未接受HAART治疗的患者中CD56(dim)自然杀伤细胞选择性减少。接受HAART治疗的患者中，CD161+CD56(dim)自然杀伤细胞数量显著减少。在所有三组中，CD56(dim)产生γ干扰素的能力相同。与健康对照者相比，接受HAART治疗患者的TNFα+CD56(bright)自然杀伤细胞数量以及未接受HAART治疗患者的TNFα+CD56(dim)自然杀伤细胞数量均显著减少。总之，我们的数据显示，HIV患者淋巴细胞上凝集素样受体的功能能力和共表达模式分别因治疗状态（接受HAART治疗或未接受HAART治疗）或细胞类型（自然杀伤细胞或T细胞）而受到不同影响。
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