基于表型分析的自然杀伤细胞系淋巴增殖性疾病的分化阶段
Differentiation stage of natural killer cell-lineage lymphoproliferative disorders based on phenotypic analysis.
作者信息
Mori K L, Egashira M, Oshimi K
机构信息
Department of Haematology, Juntendo University of School of Medicine, Tokyo, Japan.
出版信息
Br J Haematol. 2001 Oct;115(1):225-8. doi: 10.1046/j.1365-2141.2001.03038.x.
In the normal developmental pathway of natural killer (NK) cells, pre-NK cells express CD161, immature NK cells express CD161 and CD56, and mature NK cells express CD161, CD56 and CD94. To identify the normal counterpart of NK cells from which neoplastic cells originate, surface antigens were analysed. Blastic NK-cell lymphoma/leukaemia lacked CD94 and CD161 but had CD56. Aggressive NK-cell leukaemia/lymphoma and nasal NK-cell lymphoma, although morphologically immature, expressed both CD56 and CD94 and strong NK activity. Cells from chronic NK lymphocytosis expressed CD56 and CD94.
在自然杀伤（NK）细胞的正常发育途径中，前NK细胞表达CD161，未成熟NK细胞表达CD161和CD56，成熟NK细胞表达CD161、CD56和CD94。为了鉴定肿瘤细胞起源的NK细胞的正常对应物，对表面抗原进行了分析。母细胞性NK细胞淋巴瘤/白血病缺乏CD94和CD161，但有CD56。侵袭性NK细胞白血病/淋巴瘤和鼻NK细胞淋巴瘤，尽管形态上未成熟，但表达CD56和CD94且具有较强的NK活性。慢性NK淋巴细胞增多症的细胞表达CD56和CD94。
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