Williams R L, Wilson D J, Rhodes N P
Department of Clinical Engineering, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.
Biomaterials. 2004 Aug;25(19):4659-73. doi: 10.1016/j.biomaterials.2003.12.010.
Medical-grade polydimethylsiloxane elastomer was subjected to low-powered plasma treatment in the presence of four different gases: O(2), Ar, N(2) and NH(3). Changes to the surface chemistry immediately after processing and the stability of the treatments following ageing in phosphate buffered saline or air for up to 1 month were investigated using X-ray photoelectron spectroscopy and dynamic contact angle analysis. Changes in surface morphology were assessed using optical microscopy and atomic force microscopy. All treatments resulted in an increase in wettability, attributed to major changes in chemistry combined with modest etching. Furthermore, the primary site of attack of the plasma species appeared to be dependent upon the feed gas implemented. The two main chemical changes observed after ageing were due to reactions with the storage media and relaxation processes resulting in further changes in wettability. The influence of the surface modifications on the blood compatibility of the materials was investigated by assessing contact phase activation using a partial thromboplastin time assay. It was demonstrated that the O(2) and Ar plasma treatments reduced the performance of the silicone but the N(2) and NH(3) treatments had a significantly beneficial effect on the activation of the coagulation cascade.
医用级聚二甲基硅氧烷弹性体在四种不同气体（氧气、氩气、氮气和氨气）存在的情况下接受低功率等离子体处理。使用X射线光电子能谱和动态接触角分析研究了处理后立即发生的表面化学变化以及在磷酸盐缓冲盐水或空气中老化长达1个月后处理的稳定性。使用光学显微镜和原子力显微镜评估表面形态的变化。所有处理均导致润湿性增加，这归因于化学性质的重大变化以及适度的蚀刻。此外，等离子体物质的主要攻击部位似乎取决于所使用的进料气体。老化后观察到的两个主要化学变化是由于与储存介质的反应和松弛过程导致润湿性进一步变化。通过使用部分凝血活酶时间测定法评估接触相活化来研究表面改性对材料血液相容性的影响。结果表明，氧气和氩气等离子体处理降低了硅酮的性能，但氮气和氨气处理对凝血级联反应的活化具有显著的有益作用。
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