Wilson D J, Rhodes N P, Williams R L
Department of Clinical Engineering, University of Liverpool, Duncan Building Daulby Street, Liverpool L69 3GA, UK.
Biomaterials. 2003 Dec;24(28):5069-81. doi: 10.1016/s0142-9612(03)00423-x.
A medical grade segmented polyetherurethane (PEU) was treated with a low-powered gas plasma using O(2), Ar, N(2) and NH(3) as the treatment gases. Changes in the surface functional group chemistry were studied using X-ray photoelectron spectroscopy. The wettability of the surfaces was examined using dynamic contact angle measurements and the surface morphology was evaluated using atomic force microscopy. The influence of the surface modification to the polyurethane on the blood response to the polyetherurethane was investigated by measuring changes in the activation of the contact phase activation of the intrinsic coagulation cascade. The data demonstrate that the plasma treatment process caused surface modifications to the PEU that in all cases increased the polar nature of the surfaces. O(2) and Ar plasmas resulted in the incorporation of oxygen-containing groups that remained present following storage in an aqueous environment. N(2) and NH(3) plasmas resulted in the incorporation of nitrogen-containing groups but these were replaced with oxygen-containing groups following storage in the aqueous environment. In all plasma treatments there was a lowering of contact phase activation compared to the untreated surface, the N(2) and NH(3) treatments dramatically so.
一种医用级分段聚醚聚氨酯（PEU）使用O(2)、Ar、N(2)和NH(3)作为处理气体，通过低功率气体等离子体进行处理。使用X射线光电子能谱研究表面官能团化学的变化。使用动态接触角测量检查表面的润湿性，并使用原子力显微镜评估表面形态。通过测量内源性凝血级联接触相激活的变化，研究了聚氨酯表面改性对聚醚聚氨酯血液反应的影响。数据表明，等离子体处理过程对PEU进行了表面改性，在所有情况下都增加了表面的极性。O(2)和Ar等离子体导致引入了含氧基，在水环境中储存后这些基团仍然存在。N(2)和NH(3)等离子体导致引入了含氮基团，但在水环境中储存后这些基团被含氧基取代。与未处理的表面相比，在所有等离子体处理中接触相激活都有所降低，N(2)和NH(3)处理的降低幅度显著。
