短柄舌萼叶中的抗疟药

Antiplasmodial agents from the leaves of Glossocalyx brevipes.

作者信息

Mbah James A, Tane Pierre, Ngadjui Bonaventure T, Connolly Joseph D, Okunji Christopher C, Iwu Maurice M, Schuster Brian M

机构信息

Chemistry Department, Faculty of Science, University of Dschang, Dschang, Cameroon.

出版信息

Planta Med. 2004 May;70(5):437-40. doi: 10.1055/s-2004-818972.

DOI:10.1055/s-2004-818972

PMID:15124089

Abstract

A phytochemical study of the methylene chloride/methanol (1/1) extract of the leaves of Glossocalyx brevipes Benth. (Monimiaceae) afforded three new derivatives of homogentisic acid, methyl 2-(1'beta-geranyl-5'beta-hydroxy-2'-oxocyclohex-3'-enyl)acetate (1), 2-(1'beta-geranyl-5'beta-hydroxy-2'-oxocyclohex-3'-enyl)acetic acid (2), methyl 2-(1'beta-geranyl-5'beta-hydroxy-4'beta-methoxy-2'-oxocyclohexyl)acetate (3), and two known alkaloids, aristololactam BII and liriodenine. Compounds 1 and 2 and liriodenine showed modest in vitro activity against Plasmodium falciparum.

摘要

对短柄舌萼木（Glossocalyx brevipes Benth.，樟科）叶片的二氯甲烷/甲醇（1/1）提取物进行的植物化学研究，得到了三种新的尿黑酸衍生物，2-(1'β-香叶基-5'β-羟基-2'-氧代环己-3'-烯基)乙酸甲酯（1）、2-(1'β-香叶基-5'β-羟基-2'-氧代环己-3'-烯基)乙酸（2）、2-(1'β-香叶基-5'β-羟基-4'β-甲氧基-2'-氧代环己基)乙酸甲酯（3），以及两种已知生物碱，马兜铃内酰胺BII和莲叶桐碱。化合物1、2和莲叶桐碱对恶性疟原虫显示出适度的体外活性。