Shiraishi T
Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1992 Jul;66(7):703-13.
This is a histopathological study in mice, using the tail segment of the vertebral column, to investigate the role of intervertebral disc anomalies in the development of congenital spinal deformities. The study was conducted on 222 embryos and 169 postnatal CTT (Crooked-Tailed Toden) mice, a ddY strain with hereditary crooked tails. The earliest detectable anomaly was a serpiginous deformation of the notochord during the notochord stage. Irregular lamination of dense and sparse cell layers of the sclerotome during the membrane stage followed. Then vertebral body and intervertebral disc anomalies clustered around the abnormal notochord, failing to appear separately during the cartilage stage. It was concluded that anomalies of the vertebral body do not appear independently but occur simultaneously with those of the intervertebral disc in the development of congenital spinal deformities. Disc and vertebral body anomalies appear to have equal significance in the pathogenesis of congenital spinal deformities.
这是一项在小鼠身上进行的组织病理学研究，利用脊柱的尾段来探究椎间盘异常在先天性脊柱畸形发展中的作用。该研究对222个胚胎和169只出生后的CTT（弯尾托登）小鼠进行，CTT小鼠是一种具有遗传性弯尾的ddY品系。最早可检测到的异常是在脊索阶段脊索出现蜿蜒变形。随后在膜阶段，体节的致密和稀疏细胞层出现不规则分层。然后椎体和椎间盘异常聚集在异常脊索周围，在软骨阶段未分别出现。研究得出结论，在先天性脊柱畸形的发展过程中，椎体异常并非独立出现，而是与椎间盘异常同时发生。椎间盘和椎体异常在先天性脊柱畸形的发病机制中似乎具有同等重要性。
