Mejorado Lupe H, Hoarau Christophe, Pettus Thomas R R
Department of Chemistry and Biochemistry, University of California at Santa Barbara, Santa Barbara, California 93106-9150, USA.
Org Lett. 2004 May 13;6(10):1535-8. doi: 10.1021/ol0498592.
An operationally simple oxidative dearomatization of resorcinol derivatives is reported that employs an inexpensive chiral directing group. The method provides access to a variety of p-quinol derivatives in good yield and diastereoselectivity. A short reductive process affords 4-hydroxy-4-alkylcyclohexenone derivatives in excellent yields and enantiomeric excesses.
据报道,间苯二酚衍生物可通过一种操作简单的氧化脱芳构化反应实现,该反应采用了一种廉价的手性导向基团。该方法能够以良好的产率和非对映选择性获得多种对苯二酚衍生物。一个简短的还原过程能够以优异的产率和对映体过量值得到4-羟基-4-烷基环己烯酮衍生物。