Glocker Erik, Kist Manfred
Department of Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Hospital Freiburg, 79104 Freiburg, Germany.
J Clin Microbiol. 2004 May;42(5):2241-6. doi: 10.1128/JCM.42.5.2241-2246.2004.
As a result of the increasing resistance of Helicobacter pylori against first-line antibiotics, other drugs, such as quinolones, will be needed for eradication therapy in the future. We developed a real-time PCR to detect mutations in the gyrA gene associated with ciprofloxacin resistance of H. pylori, thereby contributing to the selection of patients who could be treated by ciprofloxacin-based therapy.
由于幽门螺杆菌对一线抗生素的耐药性不断增加,未来根除治疗将需要其他药物,如喹诺酮类药物。我们开发了一种实时PCR技术,用于检测与幽门螺杆菌对环丙沙星耐药性相关的gyrA基因突变,从而有助于选择可以接受基于环丙沙星治疗的患者。