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自我报告的依从性和血浆非核苷类逆转录酶抑制剂/蛋白酶抑制剂浓度对预测初始接受高效抗逆转录病毒治疗有反应患者病毒学反弹的相对预后价值。

Relative prognostic value of self-reported adherence and plasma NNRTI/PI concentrations to predict virological rebound in patients initially responding to HAART.

作者信息

Antinori Andrea, Cozzi-Lepri Alessandro, Ammassari Adriana, Trotta Maria Paola, Nauwelaers David, Hoetelmans Richard, Murri Rita, Melzi Sara, Narciso Pasquale, Nasta Paola, Zaccarelli Mauro, Santopadre Paola, Vecchiet Jacopo, Izzo Crescenzo Maria, Maonforte Antonella d'Arminio

机构信息

Istituto Nazionale per le Malattie Infettive, L Spallanzani IRCCS, Roma, Italy.

出版信息

Antivir Ther. 2004 Apr;9(2):291-6.

PMID:15134192
Abstract

We studied the predictive value of self-reported adherence and plasma drug concentrations on virological rebound to HAART. Among 238 participants in the AdICoNA study who had viral load < or = 500 copies/ml, 42 (17.6%) experienced virological rebound by 96 weeks. Both self-reported non-adherence and sub-optimal concentration were independently associated with a higher risk of virological rebound.

摘要

我们研究了自我报告的依从性和血浆药物浓度对高效抗逆转录病毒治疗（HAART）病毒学反弹的预测价值。在AdICoNA研究中病毒载量≤500拷贝/ml的238名参与者中，42名（17.6%）在96周时出现病毒学反弹。自我报告的不依从和次优浓度均与病毒学反弹的较高风险独立相关。

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