Alonso C, Ramón E, Lozano C, Parra J L, Torres J L, Coderch L
Chemical and Environmental Research Institute, IIQAB, Consejo Superior de Investigaciones Científicas, Barcelona, Spain.
Drugs Exp Clin Res. 2004;30(1):1-10.
Catechins (flavanols) are strong antioxidants, free radical scavengers and inhibitors of lipid peroxidation. New bio-based antioxidant compounds obtained by depolymerization of plant polymeric flavanols (procyanidins) in the presence of cysteine or cysteamine, as well as their underivatized counterpart, (-)-epicatechin, were evaluated in terms of their percutaneous absorption profiles taking into account their free radical scavenging efficiency. The evaluation of the percutaneous absorption of flavanols was carried out by an in vitro methodology using both pig and human skin. A good correlation was obtained using both skins in the evaluation of the skin absorption profiles. It can be deduced that 4beta-(S-cysteinyl)epicatechin (Cys-Ec) has a tendency to be located mainly in the outermost layers of the skin, whereas 4beta-(2-aminoethylthio)epicatechin (Cya-Ec) has a pronounced percutaneous absorption capacity. Their antioxidant properties and their skin penetration profiles support their potential cosmetic or pharmacological applications.
儿茶素（黄烷醇）是强大的抗氧化剂、自由基清除剂和脂质过氧化抑制剂。在半胱氨酸或半胱胺存在下通过植物聚合黄烷醇（原花青素）解聚获得的新型生物基抗氧化化合物，以及它们的未衍生化对应物（-）-表儿茶素，在考虑其自由基清除效率的情况下，对其经皮吸收情况进行了评估。使用猪皮和人皮通过体外方法对黄烷醇的经皮吸收进行了评估。在评估皮肤吸收情况时，使用两种皮肤都获得了良好的相关性。可以推断，4β-（S-半胱氨酰基）表儿茶素（Cys-Ec）倾向于主要位于皮肤的最外层，而4β-（2-氨基乙硫基）表儿茶素（Cya-Ec）具有明显的经皮吸收能力。它们的抗氧化特性和皮肤渗透情况支持它们在化妆品或药理学方面的潜在应用。
