高功能自闭症谱系障碍患者清醒和快速眼动睡眠状态下的脑电图频谱分析

EEG spectral analysis of wakefulness and REM sleep in high functioning autistic spectrum disorders.

作者信息

Daoust Anne-Marie, Limoges Elyse, Bolduc Christianne, Mottron Laurent, Godbout Roger

机构信息

Neurodevelopmental Disorders Program, Laboratoire du Sommeil, Centre de Recherche Fernand-Seguin, Hôpital Rivière-des-Prairies, 7070 Boulevard Perras, Montreal, Quebec, Canada H1E 1A4.

出版信息

Clin Neurophysiol. 2004 Jun;115(6):1368-73. doi: 10.1016/j.clinph.2004.01.011.

DOI:10.1016/j.clinph.2004.01.011

PMID:15134704

Abstract

OBJECTIVE

The aim of this study was to investigate the involvement of temporo-occipital regions in the pathophysiology of autistic spectrum disorders (ASD) by using REM sleep and waking EEG.

METHODS

The EEG recordings of 9 persons with ASD and 8 control participants were recorded using a 12-electrode montage. Spectral analysis (0.75-19.75 Hz) was performed on EEG activity recorded upon two activated states: REM sleep and wakefulness.

RESULTS

During REM sleep, persons with ASD showed a selective, significantly lower absolute beta (13.0-19.75 Hz) spectral amplitude over the primary (O(1), O(2)) and associative (T(5), T(6)) cortical visual areas compared to controls. Persons with ASD showed significantly higher absolute theta (4.0-7.75 Hz) spectral amplitude over the left frontal pole region (Fp1) compared to controls during evening wakefulness, but not during morning wakefulness.

SIGNIFICANCE

The results of waking EEG are consistent with previously reported observations of neuropsychological signs of frontal atypicalities in ASD; results from REM sleep are the first EEG evidence to support the hypothesis of abnormal visuoperceptual functioning in ASD. Altogether, these results point toward atypical thalamo-cortical mechanisms subserving the neural processing of information in ASD.

摘要

目的

本研究旨在通过快速眼动（REM）睡眠和清醒脑电图来探究颞枕叶区域在自闭症谱系障碍（ASD）病理生理学中的作用。

方法

使用12电极导联对9名自闭症患者和8名对照参与者进行脑电图记录。对在两种激活状态（REM睡眠和清醒）下记录的脑电活动进行频谱分析（0.75 - 19.75赫兹）。

结果

在REM睡眠期间，与对照组相比，自闭症患者在初级（O(1)，O(2)）和联合（T(5)，T(6)）皮质视觉区域表现出选择性的、显著更低的绝对β波（13.0 - 19.75赫兹）频谱振幅。与对照组相比，自闭症患者在夜间清醒时，左额极区（Fp1）的绝对θ波（4.0 - 7.75赫兹）频谱振幅显著更高，但在早晨清醒时并非如此。