Bassett Mary H, White Perrin C, Rainey William E
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9032, USA.
Mol Cell Endocrinol. 2004 Mar 31;217(1-2):67-74. doi: 10.1016/j.mce.2003.10.011.
Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is controlled, in large part, by the regulated transcription of CYP11B2, the gene encoding aldosterone synthase. Aldosterone synthase is responsible for the conversion of 11-deoxycorticosterone to aldosterone and is expressed only within the zona glomerulosa of the adrenal cortex. The development of new systems for in vitro studies of expression has helped define molecular mechanisms that regulate this enzyme and thus the capacity of the adrenal gland to produce aldosterone. Both potassium and angiotensin II (ANG II) increase intracellular calcium levels, which regulate expression of CYP11B2 through transcription factors that interact with defined sites in the 5'-flanking region of the gene.
醛固酮是人体内主要的盐皮质激素，是血管内容量和血压的主要调节因子。肾上腺产生醛固酮的能力在很大程度上受CYP11B2（编码醛固酮合酶的基因）转录调控。醛固酮合酶负责将11 - 脱氧皮质酮转化为醛固酮，且仅在肾上腺皮质的球状带中表达。用于该表达体外研究的新系统的开发，有助于明确调节这种酶的分子机制，进而明确肾上腺产生醛固酮的能力。钾和血管紧张素II（ANG II）均可提高细胞内钙水平，二者通过与该基因5'侧翼区域特定位点相互作用的转录因子来调节CYP11B2的表达。
