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氟烷对儿童视网膜电图的影响。

Effects of halothane on children's electroretinograms.

作者信息

Wongpichedchai S, Hansen R M, Koka B, Gudas V M, Fulton A B

机构信息

Department of Ophthalmology, Children's Hospital, Boston, MA 02115.

出版信息

Ophthalmology. 1992 Aug;99(8):1309-12. doi: 10.1016/s0161-6420(92)31810-x.

Abstract

BACKGROUND

At times, anesthesia is necessary to test children's electroretinographic (ERG) responses. Halothane, an anesthetic commonly used for pediatric patients, affects some aspects of ERG responses, but it is unknown if halothane affects ERG parameters evaluated by contemporary clinical protocols.

METHODS

Scotopic and photopic ERG responses were recorded from children when awake and then under halothane.

RESULTS

Halothane has no effect on scotopic b-wave stimulus/response parameters, including amplitude, sensitivity, and implicit time. Scotopic a-wave amplitudes, implicit times, model parameters, and ratio of a- to b-wave amplitudes are unaffected by halothane. The amplitudes and implicit times of photopic responses to red flashes and 30 Hz flickering white light are not altered by halothane. Halothane causes no significant change in amplitudes and implicit times of the oscillatory potential wavelets.

CONCLUSION

These results suggest that significant departures of ERG responses (studied with the protocol described herein) from a laboratory's normal values cannot be attributed to halothane.

摘要

背景

有时,进行儿童视网膜电图(ERG)反应测试时需要麻醉。氟烷是一种常用于儿科患者的麻醉剂,会影响ERG反应的某些方面,但氟烷是否会影响当代临床方案所评估的ERG参数尚不清楚。

方法

记录儿童清醒时以及使用氟烷麻醉时的暗视和明视ERG反应。

结果

氟烷对暗视b波刺激/反应参数无影响,包括振幅、敏感度和潜伏时间。暗视a波振幅、潜伏时间、模型参数以及a波与b波振幅之比不受氟烷影响。氟烷不会改变对红色闪光和30Hz闪烁白光的明视反应的振幅和潜伏时间。氟烷对振荡电位小波的振幅和潜伏时间无显著影响。

结论

这些结果表明,(采用本文所述方案研究的)ERG反应与实验室正常值的显著差异不能归因于氟烷。

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