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0.15赫兹频段的心血管节律:人和狗脑干网状结构中相同现象的共同起源?

Cardiovascular rhythms in the 0.15-Hz band: common origin of identical phenomena in man and dog in the reticular formation of the brain stem?

作者信息

Perlitz Volker, Lambertz Manfred, Cotuk Birol, Grebe Reinhard, Vandenhouten Ralf, Flatten Guido, Petzold Ernst Richard, Schmid-Schönbein Holger, Langhorst Peter

机构信息

Psychophysiologisches Labor, Klinik für Psychosomatik und Psychotherapeutische Medizin, Medizinische Fakultät der Rheinisch-Westfälisch-Technischen Hochschule Aachen, 52057 Aachen, Germany.

出版信息

Pflugers Arch. 2004 Sep;448(6):579-91. doi: 10.1007/s00424-004-1291-4. Epub 2004 May 12.

Abstract

Selected examples from experiments in humans and dogs with time series of reticular neurons, respiration, arterial blood pressure and cutaneous forehead blood content fluctuations were analysed using multiscaled time-frequency distribution, post-event-scan and pointwise transinformation. We found in both experiments a "0.15-Hz rhythm" exhibiting periods of spindle waves (increasing and decreasing amplitudes), phase synchronized with respiration at 1:2 and 1:1 integer number ratios. At times of wave-epochs and n:m phase synchronization, the 0.15-Hz rhythm appeared in heart rate and arterial blood pressure. As phase synchronization of the 0.15-Hz rhythm with respiration was established at a 1:1 integer number ratio, all cardiovascular-respiratory oscillations were synchronized at 0.15 Hz. Analysis of a canine experiment supplied evidence that the emergence of the 0.15-Hz rhythm and n:m phase synchronization appears to result from a decline in the level of the general activity of the organism associated with a decline in the level of activity of reticular neurons in the lower brainstem network. These findings corroborate the notion of the 0.15-Hz rhythm as a marker of the "trophotropic mode of operation" first introduced by W.R. Hess.

摘要

我们使用多尺度时频分布、事件后扫描和逐点互信息分析了人类和狗的实验中的选定示例,这些实验涉及网状神经元、呼吸、动脉血压和前额皮肤血液含量波动的时间序列。我们在两个实验中都发现了一种“0.15赫兹节律”,其呈现出纺锤波周期(振幅增加和减小),与呼吸以1:2和1:1的整数比相位同步。在波周期和n:m相位同步时,0.15赫兹节律出现在心率和动脉血压中。由于0.15赫兹节律与呼吸的相位同步以1:1的整数比建立,所有心血管 - 呼吸振荡在0.15赫兹处同步。对犬类实验的分析提供了证据,表明0.15赫兹节律和n:m相位同步的出现似乎是由于与脑干下部网络中网状神经元活动水平下降相关的机体总体活动水平下降所致。这些发现证实了0.15赫兹节律作为W.R. Hess首次提出的“营养性运作模式”标志物的概念。

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