Lambertz M, Langhorst P
Institut für Physiologie, Freie Universität Berlin, Germany.
J Auton Nerv Syst. 1998 Jan 19;68(1-2):58-77. doi: 10.1016/s0165-1838(97)00126-4.
Several neurons from different regions of the brainstem of anesthetized dogs were simultaneously recorded, together with various parameters of the cardiovascular system, respiration, efferent sympathetic neural activities and cortical activity. Often rhythmic changes of activity in the range 0.05-0.5 Hz could be observed in the simultaneously recorded signals. The rhythms were analysed in time domain and by power spectra and their changes depicted over the time. The most striking rhythms between 0.05 Hz and 0.5 Hz are the respiratory rhythm and those rhythms that originate in reticular neurons of the common brainstem system as well as their respective harmonics, i.e. the ranges around the integer multiple frequencies of these basic rhythms. The observed oscillations can vanish and reappear at times. Frequencies of basic oscillations and harmonics and their amplitudes are subject to distinct slow modulations. These modulations can have irregular as well as regular courses. The different rhythms can appear separately or simultaneously in the single signals. The most important phenomenon to be observed is that the rhythms mutually influence their frequencies, which follows the rules of 'relative coordination' as described by E. v. Holst. Such changes of rhythmic activities generally also concern the ranges of harmonics of the basic rhythms. Rhythmic influences on peripheral functional systems, e.g. the cardiovascular system, are most distinct at times when the different rhythms overlap in their frequency ranges. This holds not only for the ranges of basic frequencies, but also for the ranges of their harmonics. Further it was found that rhythms with the same basic frequencies may not only appear simultaneously, but also at various times in the different functional systems. The temporal course of changes of these rhythms, their interactions and their influence on the processing of cardiac rhythmic neuronal discharge patterns is demonstrated. The meaning of the mutually influencing rhythms for the functional organization of central nervous structures is discussed.
对麻醉犬脑干不同区域的多个神经元进行了同步记录，同时记录了心血管系统、呼吸、传出交感神经活动和皮层活动的各种参数。在同步记录的信号中，经常可以观察到频率在0.05 - 0.5赫兹范围内的节律性变化。对这些节律在时域和功率谱中进行了分析，并描绘了它们随时间的变化。在0.05赫兹至0.5赫兹之间最显著的节律是呼吸节律以及起源于共同脑干系统网状神经元的那些节律及其各自的谐波，即这些基本节律整数倍频率附近的范围。观察到的振荡有时会消失并重新出现。基本振荡及其谐波的频率和幅度会受到明显的缓慢调制。这些调制可以有不规则的以及规则的过程。不同的节律可以在单个信号中单独出现或同时出现。要观察到的最重要现象是这些节律相互影响它们的频率，这遵循E. v. 霍尔斯特所描述的“相对协调”规则。这种节律活动的变化通常也涉及基本节律谐波的范围。对周围功能系统，如心血管系统的节律性影响，在不同节律的频率范围重叠时最为明显。这不仅适用于基本频率范围，也适用于它们的谐波范围。此外还发现，具有相同基本频率的节律不仅可以同时出现，而且可以在不同功能系统中的不同时间出现。展示了这些节律变化的时间过程、它们的相互作用以及它们对心脏节律性神经元放电模式处理的影响。讨论了相互影响的节律对中枢神经结构功能组织的意义。
