Zhou Shao-hua, Xiao Xiao-he, Yuan Hai-long, Zhao Yan-ling, Shan Li-mei, Cai Guang-ming
Department of Pharmacy, No. 302 Hospital of PLA, Beijing 100039, China.
Zhongguo Zhong Yao Za Zhi. 2003 Jul;28(7):589-92.
By referred to a lot of data, some new drug delivery systems(DDSs) including the Sustained and Controlled DDS, the Targeted DDS, the Transdermal DDS, the Bioadhensive DDS, the PowderJect DDS and the Self-Emulsifying DDS and their applications in TCD since 2000, will be summarized and some latest DDSs in the world including drug-eluting stents, gene therapy carrier system, biological chip, biomolecular motor-powered nanodevice and nanotrap will be also introduced in this paper. The objective of this paper is to introduce the new DDSs proceedings of and their applications in the Traditional Chinese Drugs(TCDs) and to provide some references for the pharmaceutics of TCD. For several recent years, the great success have been achieved in studying the new DDS application in the change of preparation of TCD by the investigators at home, but there is a large difference between at home and at board. So it is necessary to make a greater advance. During the modernization of TCD, there is an effective way that the new drug delivery systems(DDSs) will be applied in the change of the preparation of TCD.
通过查阅大量资料,本文将总结自2000年以来包括缓释控释给药系统、靶向给药系统、经皮给药系统、生物黏附给药系统、粉末注射给药系统和自乳化给药系统等在内的一些新型给药系统(DDSs)及其在中药中的应用,同时还将介绍世界上一些最新的给药系统,包括药物洗脱支架、基因治疗载体系统、生物芯片、生物分子马达驱动的纳米装置和纳米陷阱。本文的目的是介绍新型给药系统的研究进展及其在中药(TCDs)中的应用,为中药制剂学提供一些参考。近年来,国内研究者在新型给药系统应用于中药制剂变革方面取得了很大成功,但国内外仍存在较大差距,因此有必要取得更大进展。在中药现代化过程中,将新型给药系统(DDSs)应用于中药制剂变革是一条有效途径。