来自海洋海绵Thorectandra sp.的细胞毒性生物碱

Cytotoxic alkaloids from the marine sponge Thorectandra sp.

作者信息

Charan Romila D, McKee Tawnya C, Boyd Michael R

机构信息

Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA.

出版信息

Nat Prod Res. 2004 Jun;18(3):225-9. doi: 10.1080/14786410310001622077.

DOI:10.1080/14786410310001622077

PMID:15143832

Abstract

Three beta-carboline alkaloids, Compound 1, 1-deoxysecofascaplysin A (2), and fascaplysin (3), were isolated from the aqueous and organic extracts of the marine sponge Thorectandra sp. The structures of 1 and 2 were determined on the basis of spectral data. Compound 1 inhibited the growth of MCF-7 (breast) with an IC50 of 5.9 microg/mL while Compound 2 inhibited the growth of MCF-7 as well as OVCAR-3 (ovarian) human tumor cell lines with IC50s of 1.5 and 2.2 microg/mL, respectively.

摘要

从海洋海绵Thorectandra sp.的水提取物和有机提取物中分离出三种β-咔啉生物碱，即化合物1、1-脱氧secofascaplysin A（2）和fascaplysin（3）。根据光谱数据确定了化合物1和2的结构。化合物1对MCF-7（乳腺癌）细胞生长具有抑制作用，IC50为5.9微克/毫升，而化合物2对MCF-7以及OVCAR-3（卵巢癌）人肿瘤细胞系的生长均有抑制作用，IC50分别为1.5和2.2微克/毫升。