从地中海海洋海绵拉卡泽氏瘤背海绵中分离得到的托普森汀类和哈马坎汀类新型双吲哚生物碱。

New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.

作者信息

Casapullo A, Bifulco G, Bruno I, Riccio R

机构信息

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo, Fisciano (SA) 84084, Italy.

出版信息

J Nat Prod. 2000 Apr;63(4):447-51. doi: 10.1021/np9903292.

DOI:10.1021/np9903292

PMID:10785411

Abstract

Chemical investigation of the Et(2)O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human bronchopulmonary cancer cells (NSCLC-N6) with an IC(50) of 12 and 6.3 microg/mL, respectively.

摘要

对海洋海绵拉卡氏拟线海绵的乙醚提取物进行化学研究，从中分离出13种纯双吲哚生物碱（1 - 13）。化合物（1 - 6）属于托普西汀类，此前已有报道。化合物7 - 13是与哈马坎辛类密切相关的新产物。对主要化合物1 - 3进行了体外抗肿瘤活性测试；化合物2和3对人支气管肺癌细胞（NSCLC - N6）显示出抗增殖活性，IC50分别为12和6.3微克/毫升。