Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
J Nat Prod. 2010 Feb 26;73(2):258-62. doi: 10.1021/np9005629.
Two new pyrroloiminoquinone alkaloids of the discorhabdin class, along with 12 compounds including one previously described synthetic derivative of the same and related skeletal classes, were isolated from the sponge Sceptrella sp., collected from Gageodo, Korea. The structures of these new compounds, designated as (-)-3-dihydrodiscorhabdin D (11) and (-)-discorhabdin Z (12), were determined by combined spectroscopic analyses. Compound 12 possesses an unusual hemiaminal group among the discorhabdin alkaloids. These compounds exhibited moderate to significant cytotoxicity, antibacterial activity, and inhibitory activity against sortase A.
从韩国盖多岛采集的海绵 Sceptrella sp. 中分离得到两个新的吡咯并 iminoquinone 生物碱类 discorhabdin 化合物，以及包括一个以前描述的同一和相关骨架类别的合成衍生物在内的 12 种化合物。这些新化合物的结构通过组合光谱分析确定，分别命名为 (-)-3-二氢 discorhabdin D (11) 和 (-)-discorhabdin Z (12)。化合物 12 在 discorhabdin 生物碱中具有不寻常的半亚胺基团。这些化合物表现出中等至显著的细胞毒性、抗菌活性和对 sortase A 的抑制活性。
