日本的体重指数与死亡率：宫城队列研究
Body mass index and mortality in Japan: the Miyagi Cohort Study.
作者信息
Kuriyama Shinichi, Ohmori Kaori, Miura Chihaya, Suzuki Yoko, Nakaya Naoki, Fujita Kazuki, Sato Yuki, Tsubono Yoshitaka, Tsuji Ichiro, Fukao Akira, Hisamichi Shigeru
机构信息
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8575, Japan.
出版信息
J Epidemiol. 2004 Feb;14 Suppl 1(Suppl I):S33-8. doi: 10.2188/jea.14.s33.
BACKGROUND
The relation between body mass index (BMI) and mortality is not well established. The objective of this study was to examine the association in Japanese adults.
METHODS
In 1990, 18,740 men and 20,870 women in Miyagi Prefecture in rural northern Japan (40-64 years of age) completed a self-administered questionnaire including height and weight. Cox regression was used to estimate relative risk (RR) of mortality according to levels of BMI, with adjustment for age, marital status, smoking, drinking, walking, and weight change since 20 years of age.
RESULTS
During 11 years of follow-up, 1,121 men and 567 women had died. Compared with the referent BMI category (23.0-24.9), women in the highest BMI category (BMI>30.0) had a RR of death of 1.64 (95% confidence interval (CI), 1.09-2.49) and men and women in the lowest BMI categories (BM1<18.5) had a RR of death of 2.06 (95% CI, 1.49-2.84) and 1.83 (95% CI, 1.17-2.88), respectively, after adjustment for potential confounders and after exclusion of deaths occurring in the first three years of follow-up. We did not observe significant differences in mortality for subjects with wide range of BMI (18.5 or higher in men and 18.5 to 29.9 in women).
CONCLUSIONS
The risk of death from all causes increases in lean men and women, and obese women in this cohort.
背景
体重指数（BMI）与死亡率之间的关系尚未完全明确。本研究旨在调查日本成年人中的这种关联。
方法
1990年，日本北部农村宫城县的18740名男性和20870名女性（年龄在40 - 64岁之间）完成了一份包含身高和体重的自填式问卷。采用Cox回归根据BMI水平估计死亡率的相对风险（RR），并对年龄、婚姻状况、吸烟、饮酒、步行情况以及自20岁起的体重变化进行了调整。
结果
在11年的随访期间，1121名男性和567名女性死亡。与参考BMI类别（23.0 - 24.9）相比，BMI最高类别（BMI>30.0）的女性死亡RR为1.64（95%置信区间（CI），1.09 - 2.49），BMI最低类别（BMI<18.5）的男性和女性死亡RR分别为2.06（95%CI，1.49 - 2.84）和1.83（95%CI，1.17 - 2.88），这是在调整了潜在混杂因素并排除随访前三年发生的死亡病例之后得出的结果。我们未观察到BMI范围较宽的受试者（男性BMI为≥18.5，女性BMI为18.5至29.9）在死亡率上有显著差异。
结论
在该队列中，偏瘦的男性和女性以及肥胖女性的全因死亡风险增加。
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