循环系统中化合物A和一氧化碳的产生：两种二氧化碳吸收剂的体外比较

Production of compound A and carbon monoxide in circle systems: an in vitro comparison of two carbon dioxide absorbents.

作者信息

Struys M M R F, Bouche M P L A, Rolly G, Vandevivere Y D I, Dyzers D, Goeteyn W, Versichelen L F M, Van Bocxlaer J F P, Mortier E P

机构信息

Department of Anaesthesia, Ghent University Hospital, Ghent, Belgium.

出版信息

Anaesthesia. 2004 Jun;59(6):584-9. doi: 10.1111/j.1365-2044.2004.03704.x.

DOI:10.1111/j.1365-2044.2004.03704.x

PMID:15144299

Abstract

Two new generation carbon dioxide absorbents, DrägerSorb Free and Amsorb Plus, were studied in vitro for formation of compound A or carbon monoxide, during minimal gas flow (500 ml x min(-1)) with sevoflurane or desflurane. Compound A was assessed by gas chromatography/mass spectrometry and carbon monoxide with continuous infrared spectrometry. Fresh and dehydrated absorbents were studied. Mean (SD) time till exhaustion (inspiratory carbon dioxide concentration >or= 1 kPa) with fresh absorbents was longer with DrägerSorb Free (1233 (55) min) than with Amsorb Plus (1025 (55) min; p < 0.01). For both absorbents, values of compound A were < 1 ppm and therefore below clinically significant levels, but were up to 0.25 ppm higher with DrägerSorb Free than with Amsorb Plus. Using dehydrated absorbents, values of compound A were about 50% lower than with fresh absorbents and were identical for DrägerSorb Free and Amsorb Plus. With dehydrated absorbents, no detectable carbon monoxide was found with desflurane.

摘要

在体外研究了两种新一代二氧化碳吸收剂——DrägerSorb Free和Amsorb Plus，在七氟醚或地氟醚最低气流（500 ml x min(-1)）条件下生成化合物A或一氧化碳的情况。通过气相色谱/质谱法评估化合物A，用连续红外光谱法评估一氧化碳。研究了新鲜和脱水的吸收剂。新鲜吸收剂的平均（标准差）耗尽时间（吸气二氧化碳浓度≥1 kPa），DrägerSorb Free（1233（55）分钟）比Amsorb Plus（1025（55）分钟；p<0.01）更长。对于两种吸收剂，化合物A的值均<1 ppm，因此低于临床显著水平，但DrägerSorb Free比Amsorb Plus高0.25 ppm。使用脱水吸收剂时，化合物A的值比新鲜吸收剂低约50%，且DrägerSorb Free和Amsorb Plus相同。使用脱水吸收剂时，地氟醚未检测到一氧化碳。