Kobayashi Shunji, Bito Hiromichi, Morita Koji, Katoh Takasumi, Sato Shigehito
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan.
J Anesth. 2004;18(4):277-81. doi: 10.1007/s00540-004-0253-5.
The properties of two new-generation CO(2) absorbents, Amsorb Plus (Armstrong Medical, Coleraine, UK) and Drägersorb Free (Drager, Lubeck, Germany), were compared with those of Amsorb (Armstrong Medical) and Sodasorb II (W.R. Grace, Lexington, MA, USA).
The concentration of compound A produced by each absorbent was determined in a low-flow circuit containing sevoflurane, and the CO(2) absorption capacity of the absorbent was measured. The circuit contained 1000 g of each absorbent and had a fresh gas (O(2)) flow rate of 1 l.min(-1) containing 2% sevoflurane. CO(2) was delivered to the circuit at a flow rate of 200 ml.min(-1).
The maximum concentrations of compound A were 2.2 +/- 0.0, 2.3 +/- 0.3, 2.2 +/- 0.2, and 23.5 +/- 1.5 ppm (mean +/- SD) for Amsorb Plus, Drägersorb Free, Amsorb, and Sodasorb II, respectively. The maximum concentration of compound A for Sodasorb II was significantly higher than those for the other absorbents (P < 0.01). The CO(2) absorption capacities (time taken to reach an inspiratory CO(2) level of 2 mmHg) were 1023 +/- 48, 1074 +/- 36, 767 +/- 41, and 1084 +/- 54 min, respectively, and the capacity of Amsorb was significantly lower than that of the other absorbents (P < 0.01).
The new-generation carbon dioxide absorbents, Amsorb Plus and Drägersorb Free, produce a low concentration of compound A in the circuit while showing sufficient CO(2) absorption capacity.
比较两种新一代二氧化碳吸收剂Amsorb Plus（英国科勒雷恩的阿姆斯特朗医疗公司）和Drägersorb Free（德国吕贝克的德尔格公司）与Amsorb（阿姆斯特朗医疗公司）和Sodasorb II（美国马萨诸塞州列克星敦的W.R.格雷斯公司）的性能。
在含有七氟醚的低流量回路中测定每种吸收剂产生的化合物A的浓度，并测量吸收剂的二氧化碳吸收能力。回路中每种吸收剂为1000克，新鲜气体（氧气）流速为1升·分钟⁻¹，含2%七氟醚。二氧化碳以200毫升·分钟⁻¹的流速输送至回路。
Amsorb Plus、Drägersorb Free、Amsorb和Sodasorb II产生的化合物A的最大浓度分别为2.2±0.0、2.3±0.3、2.2±0.2和23.5±1.5 ppm（平均值±标准差）。Sodasorb II的化合物A最大浓度显著高于其他吸收剂（P<0.01）。二氧化碳吸收能力（达到吸气二氧化碳水平2 mmHg所需时间）分别为1023±48、1074±36、767±41和1084±54分钟，Amsorb的吸收能力显著低于其他吸收剂（P<0.01）。
新一代二氧化碳吸收剂Amsorb Plus和Drägersorb Free在回路中产生低浓度的化合物A，同时显示出足够的二氧化碳吸收能力。
