Casanova Jean-Laurent, Abel Laurent
Pediatric Hematology-Immunology Unit, Necker Enfants-Malades Hospital, Paris, France.
J Exp Med. 2004 May 17;199(10):1295-9. doi: 10.1084/jem.20040537.
Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, approximately 5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.
人甘露糖结合凝集素（MBL）可识别多种微生物，并触发补体激活的最古老途径。然而，约5%的个体缺乏功能性血清MBL，在前瞻性研究中未发现他们易患严重感染。这些数据表明，人MBL在保护性免疫中很大程度上是多余的，甚至可能由于有害影响而受到反向选择。
