Tremblay A, Pelletier C, Doucet E, Imbeault P
Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada.
Int J Obes Relat Metab Disord. 2004 Jul;28(7):936-9. doi: 10.1038/sj.ijo.0802527.
The main objective of this study was to investigate the potential impact of body organochlorine (OC) pollution on the adaptive change in thermogenesis induced by body weight loss. Fat mass (FM), fat-free mass (FFM), and sleeping metabolic rate (SMR) were measured in obese individuals before and after a weight-reducing program. The measured values of SMR were then compared to those predicted from a reference equation established from FM and FFM in control subjects. Plasma OC, leptin, total tri-iodothyronine, and free thyroxine concentrations were also measured in obese subjects before and after weight loss. After weight loss, the measured decrease in SMR was greater than that predicted by changes in FM and FFM. Increased plasma OC concentration was the factor explaining the greatest proportion of the difference between predicted and measured SMR changes induced by body weight loss. OC pollution seems to be a new factor affecting the control of thermogenesis in some obese individuals experiencing body weight loss.
本研究的主要目的是调查身体有机氯（OC）污染对体重减轻引起的产热适应性变化的潜在影响。在减肥计划前后，对肥胖个体测量了脂肪量（FM）、去脂体重（FFM）和睡眠代谢率（SMR）。然后将测量的SMR值与根据对照组中FM和FFM建立的参考方程预测的值进行比较。还测量了肥胖受试者减肥前后的血浆OC、瘦素、总三碘甲状腺原氨酸和游离甲状腺素浓度。减肥后，测量到的SMR下降幅度大于FM和FFM变化所预测的幅度。血浆OC浓度升高是解释体重减轻引起的预测和测量的SMR变化之间差异最大比例的因素。OC污染似乎是影响一些体重减轻的肥胖个体产热控制的一个新因素。
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