Tremblay Angelo, Chaput Jean-Philippe
Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Que., Canada G1K 7P4.
Br J Nutr. 2009 Aug;102(4):488-92. doi: 10.1017/S0007114508207245.
Adaptive thermogenesis is defined as a greater than predicted change in energy expenditure in response to changes in energy balance. This issue is particularly relevant in the context of a weight-reducing programme in which diminished thermogenesis can be sufficient to compensate for a prescribed decrease in daily energy intake. In the present pilot study, we investigated the adaptive reduction in thermogenesis in resting state that appears to favour resistance to further weight loss. Eight obese men (mean BMI: 33.4 kg/m2, mean age: 38 years) participated in this repeated-measures, within-subject, clinical intervention. They were subjected to a weight-loss programme that consisted of a supervised diet (-2930 kJ/d) and exercise clinical intervention. The phases investigated were as follows: (i) baseline, (ii) after 5 (SE 1) kg loss of body weight (phase 1), (iii) after 10 (SE 1) kg weight loss (phase 2) and (iv) at resistance to further weight loss (plateau). At each phase of the weight-reducing programme, body weight and composition as well as RMR were measured. A regression equation was established in a control population of the same age to predict RMR in obese men at each phase of the weight-loss programme. We observed that body weight and fat mass (FM) were significantly reduced (P < 0.05), while fat-free mass remained unchanged throughout the programme. In phase 1, measured RMR had fallen by 418 kJ/d, more than predicted (P < 0.05), and this difference reached 706 kJ/d at plateau (P < 0.05 v. phase 1). A positive association (r 0.64, P < 0.05) was observed between the reduction in thermogenesis and the degree of FM depletion at plateau. The adaptive reduction in thermogenesis at plateau was substantial and represented 30.9% of the compensation in energy balance that led to resistance to further lose body weight. In conclusion, these results show that adaptive reduction in thermogenesis may contribute to the occurrence of resistance to lose fat in obese men subjected to a weight-reducing programme.
适应性产热被定义为因能量平衡变化而导致的能量消耗变化大于预期。这个问题在减肥计划中尤为重要，因为产热减少足以抵消规定的每日能量摄入减少量。在本初步研究中，我们调查了静息状态下产热的适应性降低，这种降低似乎有利于抵抗体重的进一步减轻。八名肥胖男性（平均BMI：33.4 kg/m²，平均年龄：38岁）参与了这项重复测量、受试者自身的临床干预研究。他们接受了一项减肥计划，该计划包括监督饮食（-2930 kJ/天）和运动临床干预。所研究的阶段如下：（i）基线期，（ii）体重减轻5（标准误1）kg后（阶段1），（iii）体重减轻10（标准误1）kg后（阶段2），以及（iv）抵抗体重进一步减轻（平台期）。在减肥计划的每个阶段，测量体重、身体成分以及静息代谢率（RMR）。在相同年龄的对照人群中建立了一个回归方程，以预测肥胖男性在减肥计划各阶段的RMR。我们观察到体重和脂肪量（FM）显著降低（P < 0.05），而在整个计划中去脂体重保持不变。在阶段1，测量的RMR下降了418 kJ/天，超过预期（P < 0.05），在平台期这种差异达到706 kJ/天（与阶段1相比，P < 0.05）。在平台期，观察到产热减少与FM减少程度之间存在正相关（r = 0.64，P < 0.05）。平台期产热的适应性降低幅度很大，占导致抵抗体重进一步减轻的能量平衡补偿的30.9%。总之，这些结果表明，产热的适应性降低可能导致接受减肥计划的肥胖男性出现脂肪减少抵抗。
