铑催化不对称1,4-加成反应中亲核试剂的新加入：用于合成2-芳基-4-哌啶酮的有机锌试剂的加成反应
A new entry of nucleophiles in rhodium-catalyzed asymmetric 1,4-addition reactions: addition of organozinc reagents for the synthesis of 2-aryl-4-piperidones.
作者信息
Shintani Ryo, Tokunaga Norihito, Doi Hidenori, Hayashi Tamio
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
J Am Chem Soc. 2004 May 26;126(20):6240-1. doi: 10.1021/ja048825m.
PMID:15149215
Abstract
A rhodium-catalyzed asymmetric 1,4-addition reaction has been applied to the synthesis of 2-aryl-4-piperidones. While other conventional nucleophiles fail, organozinc reagents have been successfully utilized for the construction of these useful compounds in very good yield and enantiomeric excess.
摘要
铑催化的不对称1,4-加成反应已应用于2-芳基-4-哌啶酮的合成。当其他传统亲核试剂失效时，有机锌试剂已成功用于构建这些有用的化合物，产率和对映体过量均非常好。
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