铑催化的芳基硼酸对β-邻苯二甲酰亚氨基丙烯酸酯的不对称加成反应，用于β-氨基酸的合成。
Rhodium-catalyzed asymmetric addition of arylboronic acids to beta-phthaliminoacrylate esters toward the synthesis of beta-amino acids.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
出版信息
J Am Chem Soc. 2010 Jan 20;132(2):464-5. doi: 10.1021/ja909642h.
PMID:20028118
Abstract
Rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to beta-phthaliminoacrylate esters took place efficiently to give high yields of beta-aryl-beta-amino acid esters with 96-99% enantioselectivity, which was realized by use of a hydroxorhodium/chiral diene complex.
摘要
铑催化的芳基硼酸对β-邻苯二甲酰亚胺基丙烯酸酯的不对称 1,4-加成反应高效进行，以高收率得到了β-芳基-β-氨基酸酯，对映选择性为 96-99%，这是通过使用羟铑/手性二烯配合物实现的。
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