不对称镍催化仲α-溴代酰胺与有机锌试剂的根岸交叉偶联反应。
Asymmetric nickel-catalyzed Negishi cross-couplings of secondary alpha-bromo amides with organozinc reagents.
作者信息
Fischer Christian, Fu Gregory C
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
J Am Chem Soc. 2005 Apr 6;127(13):4594-5. doi: 10.1021/ja0506509.
PMID:15796523
Abstract
A Ni/Pybox catalyst achieves the asymmetric cross-coupling of secondary alpha-bromo amides with organozinc reagents. The process tolerates a variety of functional groups and affords the desired product in good yield and in high enantiomeric excess.
摘要
一种镍/吡啶双噁唑啉催化剂实现了仲α-溴代酰胺与有机锌试剂的不对称交叉偶联反应。该反应过程能耐受多种官能团，并以良好的产率和高对映体过量得到所需产物。
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