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不同固体模体中低能近距离治疗籽源的径向剂量函数:EGSnrc和MCNP4C蒙特卡罗代码计算结果与测量结果的比较

The radial dose function of low-energy brachytherapy seeds in different solid phantoms: comparison between calculations with the EGSnrc and MCNP4C Monte Carlo codes and measurements.

作者信息

Reniers B, Verhaegen F, Vynckier S

机构信息

Cliniques Universitaires Saint-Luc, Service de Radiothérapie Oncologique, Université Catholique de Louvain, Bruxelles, Belgium.

出版信息

Phys Med Biol. 2004 Apr 21;49(8):1569-82. doi: 10.1088/0031-9155/49/8/014.

Abstract

The use of low-energy photon emitters for brachytherapy applications, as in the treatment of the prostate or of eye tumours, has drastically increased in the last few years. New seed models for 103Pd and 125I have recently been introduced. The American Association of Physicists in Medicine recommends that measurements are made to obtain the dose rate constant, the radial dose function and the anisotropy function. These results must then be compared with Monte Carlo calculations to finally obtain the dosimetric parameters in liquid water. We have used the results obtained during the characterization of the new InterSource (furnished by IBt, Seneffe, Belgium) palladium and iodine sources to compare two Monte Carlo codes against experiment for these low energies. The measurements have been performed in three different media: two solid water plastics, WT1 and RW1, and polymethylmetacrylate. The Monte Carlo calculations were made using two different codes: MCNP4C and EGSnrc. These codes use photon cross-section data of a different origin. Differences were observed between both sets of input data below 100 keV, especially for the photoelectric effect. We obtained differences in the radial dose functions calculated with each code, which can be explained by the difference between the input data. New cross-section data were then tested for both codes. The agreement between the calculations using these new libraries is excellent. The differences are within the statistical uncertainties of the calculations. These results were compared with the experimental data. A good agreement is reached for both isotopes and in the three phantoms when the measured values are corrected for the presence of the TLDs in the phantom.

摘要

在过去几年中,低能光子发射体在近距离放射治疗中的应用急剧增加,例如用于前列腺癌或眼部肿瘤的治疗。最近引入了用于¹⁰³Pd和¹²⁵I的新型籽源模型。美国医学物理师协会建议进行测量以获得剂量率常数、径向剂量函数和各向异性函数。然后必须将这些结果与蒙特卡罗计算结果进行比较,最终获得液态水中的剂量学参数。我们利用在新型InterSource(由比利时塞内夫的IBt公司提供)钯源和碘源特性表征过程中获得的结果,针对这些低能量,将两个蒙特卡罗代码与实验进行比较。测量在三种不同介质中进行:两种固体水塑料WT1和RW1以及聚甲基丙烯酸甲酯。蒙特卡罗计算使用了两个不同的代码:MCNP4C和EGSnrc。这些代码使用不同来源的光子截面数据。在低于100 keV时,两组输入数据之间存在差异,特别是在光电效应方面。我们在使用每个代码计算的径向剂量函数中获得了差异,这可以用输入数据之间的差异来解释。然后对两个代码都测试了新的截面数据。使用这些新库进行的计算之间的一致性非常好。差异在计算的统计不确定度范围内。将这些结果与实验数据进行了比较。当对体模中TLD的存在进行校正后,两种同位素在三种体模中都达成了良好的一致性。

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