Cartelle Monica, del Mar Tomas Maria, Molina Francisca, Moure Rita, Villanueva Rosa, Bou German
Servicio de Microbiologia, Complejo Hospitalario Universitario Juan Canalejo, C/Xubias de Arriba s/n, 15006 La Coruña, Spain.
Antimicrob Agents Chemother. 2004 Jun;48(6):2308-13. doi: 10.1128/AAC.48.6.2308-2313.2004.
A clinical strain of Escherichia coli isolated from pleural liquid with high levels of resistance to cefotaxime, ceftazidime, and aztreonam harbors a novel CTX-M gene (bla(CTX-M-32)) whose amino acid sequence differs from that of CTX-M-1 by a single Asp240-Gly substitution. Moreover, by site-directed mutagenesis we demonstrated that this replacement is a key event in ceftazidime hydrolysis
从胸腔积液中分离出的一株临床大肠杆菌对头孢噻肟、头孢他啶和氨曲南具有高度耐药性,该菌携带一种新型CTX-M基因(bla(CTX-M-32)),其氨基酸序列与CTX-M-1的不同之处在于第240位氨基酸由天冬氨酸替换为甘氨酸。此外,通过定点诱变,我们证明了这种替换是头孢他啶水解的关键事件。